As if PMS, cramps, childbirth, and menopause aren't enough, research is finding that stress tends to have a longer-term effect on females than on males. Apparently, our immediate responses are similar, but it's when the cause of the stress lingers that our reactions diverge. Tests on male and female rodents (and, yes, I hate to think about that) show that, under stress, everyone's brain releases a neuropeptide that signals the body to respond to the perceived danger. But after longer periods of stress, females have more neuropeptide receptors on the surface of their nerve cells, or neurons, than males, in whom the neuropeptide moves from the membrane to the interior of the cells. Where the female is in her hormone cycle also plays a role: https://www.sciencenews.org/article/his-stress-not-her-stress
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